THE EFFECT OF DIFFERENT FREE FATTY ACID FRACTIONS FROM HYDROLYZED VIRGIN COCONUT OIL ON CHANGES OF LIPID PROFILE AND LIVER MORPHOLOGY INDUCED BY HIGH FAT DIET: AN IN VIVO STUDY

This study investigated effect of virgin coconut oil (VCO)-derived fatty acids on the alteration lipid profiles and liver tissues high fat diet (HFD) fed mice. The initial mixture was successfully obtained via hydrolysis process using Candida rugosa lipase (CRL). Enrichment medium chain (MCFA) from acid distillation developed to achieve 3 fractions including Fraction I (MCFA mainly C8 C10), II lauric (C12), III (long C14 C20). Among these agents, VCO only diminished ALT level but FFA decreased both AST levels compared with HFD-induced Moreover, showed an obvious difference in decreasing ALT, AST, total cholesterol, LDL cholesterol as well increasing HDL other agents. It observed a microvesicular steatosis mild inflammation section mice HFD whereas VCO, acids, beneficial damage.